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Research Grant Program

2019 Request for Research Proposals

The Barth Syndrome Foundation, Inc. (BSF) and its international affiliates announce the availability of funding for basic science and clinical research on the natural history, biochemical basis, and treatment of Barth syndrome. There are two basic categories: IDEA grants for 1-2 years and DEVELOPMENT grants for 2-3 years with budgetary maximums of US $50,000 or $100,000, respectively. BSF will consider any research proposal related to Barth syndrome.

BSF's Research Grant Program now requires all applicants to be independent investigators (e.g., faculty appointment). Postdoctoral fellows cannot apply. BSF allows young, non-tenured investigators to include in their submitted budget up to 75% of the total grant amount as PI salary. In addition, for those clinical applications where volunteers must travel to a clinical research site, these travel expenses will be handled separately and will be excluded from the budget maximums mentioned above. We encourage independent investigators at all professional levels to submit their best ideas. There are no geographical limitations to this funding. 


Barth syndrome (BTHS) is a serious X-linked genetic condition associated with cardiomyopathy, neutropenia, skeletal muscle weakness, exercise intolerance, growth delay, and diverse biochemical abnormalities (including defects in mitochondrial metabolism and phospholipid biosynthesis). Because many clinical and biochemical abnormalities of Barth syndrome remain poorly understood, we are seeking proposals for both basic science and clinical research that may shed light on any aspect of the syndrome with the object of developing a specific treatment or a cure.

Types of Proposals Sought

We are interested in providing “seed grant funding” to young investigators as well as attracting experienced investigators new to the field of Barth syndrome basic science or clinical research. We anticipate that these funds will be used for the testing of initial hypotheses and the collection of preliminary data leading to successful long-term funding by the National Institutes of Health (NIH) and other major granting institutions around the world.


BSF has a competitive grant process. In general terms, detailed information about the specific aims, significance, research design and methods, personnel, facilities, and budget will be required. A one-page, “Letter of Intent” is required for DEVELOPMENT grant applicants, and has a due date of September 7, 2019. The “Letter of Intent” is optional for IDEA grant applicants. We strongly encourage the submission of letters of intent before the due date to allow ample time.

Completed applications (and/or “Letters of Intent”) will be forwarded to the BSF Scientific and Medical Advisory Board (as well as to expert outside reviewers) for confidential evaluation. Response to the “Letter of Intent” will be communicated within two weeks of receipt. Based on the recommendations of the BSF Scientific and Medical Advisory Board, the BSF Board of Directors will make the final funding decisions about the grant applications. Once the final funding decisions are made, BSF affiliates will decide which, if any, of the approved grants they would like to fund. Please review our “Grants Awarded” webpage for a listing of grants that BSF and its affiliates have awarded to date.


We anticipate awarding several IDEA and DEVELOPMENT grants each year. Funds will be available soon after the successful grant applicants have been notified in late February, 2020.


The deadline for submission of the completed research grant application is October 31, 2019, and grants will be awarded in late February, 2020. The deadline for the one-page "Letter of Intent," if applicable, is September 7, 2019.

Contact Information

Erik T. Lontok, PhD
Director of Research
Barth Syndrome Foundation, Inc.
Toll Free: 855-662-2784 (855-NO-BARTH)
Local Line: 914-303-6323

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Last updated 8/7/2019

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